Doing The Keto Approach To Ketosis? You better stop: Latest Research Shows High-fat Diet combined with Age can Alter Microflora and Cause Inflammation in Heart Failure
Growing older and a high-fat diet enriched with processed omega 6 fatty acids are major contributors to health risks ranging from diabetes to heart failure. These issues can become much greater concern with the current trend to get into ketosis with The Keto Diet, characterized by a high fat, moderate to low protein, and no other carb (fruit and starches are completely excluded) except green vegetables. I have written about concerns with this approach on my Instagram account – 8 reasons you should not get into ketosis with the keto diet. But now this research shows me even more reasons for concern. You will even see one post from a follower that developed fatty liver disease after three months of being on The Keto Diet.
Ganesh Halade, Ph.D., and colleagues at the University of Alabama at Birmingham and other institutions have investigated how aging and an obesity-generating processed omega 6-enriched diet impact microflora in the gut, the structure and function of the spleen, and a subsequent immune response to heart attack,
In a study published in the FASEB Journal, they report that a calorie-dense, obesity-generating diet in aging mice disrupted the composition of the gut microbiome, and that correlated with development of a systemwide non-resolving inflammation in acute heart failure, with disruptions of the immune cell profile — notably the neutrophil-leukocyte ratio.
It is known that diet interacts with gut microbes to calibrate the body’s immune defense capacity. The UAB-led researchers examined this further, with regard to aging and a high-fat diet. They found that the obesity-generating diet caused a sharp increase in bacteria belonging to the genus Allobaculum, phylum Firmicutes. The obesity-generating diet also increased the proportion of neutrophils in the blood of young mice. In aged mice, a similar increase in the proportion of neutrophils was found for both old mice fed a standard diet and old mice fed the obesity-generating diet.
The spleen, a secondary immune organ, is a known reservoir for leukocytes that are released after heart injury. Those splenic leukocytes move to the heart to begin tissue repair and help resolve inflammation.
Importantly, young mice fed the obesity-generating diet were able to resolve inflammation after a heart attack, even though their gut microflora had already been altered by the diet. In contrast, in aged mice fed the obesity-generating diet, the heart attack triggered non-resolving inflammation. Such inflammation is associated with heart failure.
“Thus, the data strongly indicate that the obesity-generating diet develops an inflammatory microenvironment, even in young mice, that amplifies with aging,” Halade said. “This study highlights that diet and age are critical factors that have differential impact with age, and it highlights the spleen and heart as an inter-organ communication system with the immune defense system.”
What’s A Better Approach To Ketosis? Something healthier than the standard high-fat, no- carb, low to moderate protein?
The Hormone Diet Approach to Ketosis – still promotes hormone balance and is in fact anti-inflammatory. We create the circumstance where the body uses stored body fat for fuel, rather than the energy supplied through our daily dietary intake or from breaking down our muscle tissue or organs – And our diet must promote hormone balance, which means avoiding the increase in cortisol, drop in thyroid and feel good hormones (serotonin and testosterone) that is associated with The Keto Diet approach.
Remember, ketosis is a normal metabolic process, something your body does to keep working. When it doesn’t have enough carbohydrates from food for your cells to burn for energy, it burns fat instead. As part of this process, it makes ketones.
In real simple terms then, the goal is to reduce blood sugar to cause your body to tap into burning fat.
Ketosis happens when:
- We restrict sugar and carbohydrates and consume high fat (“The Keto Diet”)
- We fast – intermittent or on a daily basis.
- We exercise more and move more
- When we restrict calories (eat less – fats, carbs, sugar, meal times aka “The Bernstein Diet” )
The best approach to ketosis The Hormone Diet approach. If you eat less and exercise more, 96% of people gain the lost weight back plus more. Why?
- Cutting calories disrupts hormone balance (drops thyroid hormones, mood hormones, sex hormones and growth hormone and increases stress hormones) and causes metabolic damage that furthers the risk of future weight gain.
- If you eat less and do not exercise, overtime, you will lose metabolically active muscle. Muscle allows you to burn more fat even while you are sleeping, keeps you young and energized.
Your diet and exercise cannot be separated. When you MOVE MORE; YOU SHOULD EAT MORE. When you MOVE LESS; YOU SHOULD EAT LESS.
- NEVER USE THIS APPROACH TO LOSE WEIGHT: EAT LESS & EXERCISE MORE – as this is what is hormonally and metabolically damaging. Plus, never cut out a food group – we need them all.
How is The Hormone Diet Approach to Fat Loss & Ketosis Different?
- We start with a complete panel of blood tests that assesses every aspect of metabolic health and fat loss. This panel also includes a urine test to identify harmful imbalance of bacteria in the gut – which impacts inflammation, immunity and ability to metabolize fat loss.
- Your daily dietary intake will be linked to your movement. On the days you do not work out or do not move, you will eat less starchy carbs and less fat.
- You will still consume carbs – one fruit, loads of veggies (at least 2 cups two to three times per day), and have the option to choose one selection from a list of starchy carbs (on strength training days). This maintains cortisol, serotonin, thyroid and testosterone balance.
will consume a specific amount of protein to preserve muscle mass or to
increase muscle mass. Calculating Your Protein Intake:
- To maintain muscle (and not strength training) – 1.6 grams per kg of body weight divided into four or five meals.
- To increase muscle (and strength training) – 2.0 to 2.2 grams per kg of body weight divided into four or five meals.
- You will consume a balanced amount of healthy fats (olive oil dressing on your veggies does not count as a fat in your meals). This maintains estrogen balance. More fat on the days you move more, less on the days you move less.
- It is sustainable as all food groups are still included – and you learn to tweak your diet to prevent the saboteurs – Hunger, Energy & Cravings.
If you would like to get started on our fat loss and ketosis program or have testing done to establish the health of the bacterial balance in your gut or you metabolic profile, call 416 579 9105 or text us at 647 515 9105 or email firstname.lastname@example.org.
By Dr. Natasha Turner ND
- Vasundhara Kain, William Van Der Pol, Nithya Mariappan, Aftab Ahmad, Peter Eipers, Deanna L. Gibson, Cecile Gladine, Claire Vigor, Thierry Durand, Casey Morrow, Ganesh V. Halade. Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure. The FASEB Journal, 2019; fj.201802477R DOI: 10.1096/fj.201802477R